Research and Development
Publish the research achievements of creosote and ClO2 of Taiko Pharmaceutical
General
Ataka K., Ito M., Shibata T. YAKUGAKU ZASSHI 125, 937-950 (2005).
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New views on antidiarrheal effect of wood creosote
Baba T., Tani T. Yakushigaku Zasshi 36,10-17 (2001).
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Wood creosote: a historical study and its preparation in combination with herbal drugs
Safety Research
Kuge T., Shibata T., Willett M. S., Turck P., Traul K. A. Int J Toxicol 20, 297-305 (2001).
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Lack of oncogenicity of wood creosote, the principal active ingredient of Seirogan, an herbal antidiarrheal medication, in Sprague-Dawley rats
View Abstract(Link to NCBI PubMed)
Miyazato T., Suzuki A., Uenishi C., Yamanaka K. Oyo Yakuri 28, 925-947 (1984).
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Studies on the toxicity of beechwood creosote Chronic toxicity and carcinogenicity in rats
Miyazato T., Suzuki A., Uenishi C., Yamanaka K. Oyo Yakuri 28, 909-924 (1984).
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Studies on the toxicity of beechwood creosote Chronic toxicity and carcinogenicity in rats
Miyazato T., Suzuki A., Uenishi C., Yamanaka K. Oyo Yakuri 21, 899-919 (1981).
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Studies on the toxicity of beechwood creosote 1. Acute and subacute toxicity
Clinical Research
Kuge T., Shibata T., Willett M. S. Clin Ther 26, 1644-51 (2004).
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Multicenter, double-blind, randomized comparison of wood creosote, the principal active ingredient of Seirogan, an herbal antidiarrheal medication, and loperamide in adults with acute nonspecific diarrhea
View Abstract(Link to NCBI PubMed)
Kuge T., Shibata T., Willett M. S. Pharmacotherapy 23, 1391-1400 (2003).
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Wood creosote, the principal active ingredient of Seirogan, an herbal antidiarrheal medicine: a single-dose, dose-escalation safety and pharmacokinetic study
Kuge T., Shibata T., Willett M. S. J Clin Pharmacol 43, 284-290 (2003).
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Multiple-dose escalation, safety, and tolerability study of wood creosote, the principal active ingredient of Seirogan, an herbal antidiarrheal medication, in healthy subjects
Ogata N., Matsushima N., Shibata T. Pharmacology 51, 195-204 (1995).
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Pharmacokinetics of wood creosote: glucuronic acid and sulfate conjugation of phenolic compounds
Pharmacology Research
Ataka K., Kuge T., Fujino K., Takahashi T., Fujimiya M. Auton Neurosci 133, 136-145 (2007).
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Wood creosote prevents CRF-induced motility via 5-HT3 receptors in proximal and 5-HT4 receptors in distal colon in rats
View Abstract(Link to NCBI PubMed)
Kuge T., Greenwood-Van Meerveld B., Sokabe M. Life Sci 79, 913-918 (2006).
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Stress-induced breakdown of intestinal barrier function in the rat: reversal by wood creosote
View Abstract(Link to NCBI PubMed)
Ogata N., Shibata T. Pharmacology 72, 247-253 (2004).
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Inhibition of rat intestinal Cl- secretion by 4,5-dimethylresorcinol
Morino H., Ataka K., Ito M., Kuge T. Biol Pharm Bull 27, 1046-1051 (2004).
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Wood creosote inhibits calcium mobilization in guinea pig colonic smooth muscle
Ataka K., Kuge T., Venkova K., Greenwood-Van Meerveld B. Dig Dis Sci 48, 1303-1309 (2003).
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Seirogan (wood creosote) inhibits stress-induced ion secretion in rat intestinal epithelium
Kuge T., Venkova K., Greenwood-Van Meerveld B. Dig Dis Sci 47, 2651-2656 (2002).
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Effects of Seirogan (wood creosote) on propulsive colonic motility and stool characteristics in ambulatory mini-pigs
Kuge T., Venkova K., Greenwood-Van Meerveld B. Biol Pharm Bull 24, 623-627 (2001).
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In vitro effects of wood creosote on enterotoxin-induced secretion measured electrophysiologically in the rat jejunum and colon
Ogata N., Shibata T. Pharmacology 62, 181-187 (2001).
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Antidiarrheal activity of wood creosote: inhibition of muscle contraction and enterotoxin-induced fluid secretion in rabbit small intestine
Greenwood-Van Meerveld B., Tyler K. R., Venkova K., Kuge T. Biol Pharm Bull 23, 952-956 (2000).
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Comparison of the antidiarrheal effects of wood creosote and loperamide in the rat jejunum and colon In vitro
Ogata N., Ataka K., Morino H., Shibata T. Pharmacology 59, 212-220 (1999).
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Effect of wood creosote and loperamide on propulsive motility of mouse colon and small intestine
Greenwood-Van Meerveld B., Tyler K., Kuge T., Ogata N. Aliment Pharmacol Ther 13, 97-102 (1999).
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Anti-diarrhoeal effects of Seirogan in the rat small intestine and colon examined In vitro
View Abstract(Link to NCBI PubMed)
Sakagami Y., Ichise R., Kajimura K., Yokoyama H. Lett Appl Microbiol 28, 118-120 (1999).
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Inhibitory effect of creosote and its main components on production of verotoxin of enterohaemorrhagic Escherichia coli O157:H7
View Abstract(Link to NCBI PubMed)
Shibata T., Ogata N. J New Remedies & Clinics 47, 765-771 (1998).
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Effects of wood creosote on vero toxin-induced damage to rabbit jejunum
Ataka K., Ogata N., Kuge T., Shibata T. Res Commun Mol Pathol Pharmacol 93, 219-224 (1996).
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Suppression of enterotoxin-induced intestinal fluid secretion by wood creosote
View Abstract(Link to NCBI PubMed)
Toyoda M., Ogata N., Shibata T. Pharmacology 47, 300-308 (1993).
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Suppression of intestinal smooth muscle contraction by 4-ethylguaiacol, a constituent of wood creosote
Ogata N., Baba T., Shibata T. Pharmacology 46, 173-180 (1993).
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Demonstration of antidiarrheal and antimotility effects of wood creosote
Ogata N., Toyoda M., Shibata T. Res Commun Chem Pathol Pharmacol 77, 359-366 (1992).
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Suppression of intestinal smooth muscle contraction by phenolic compounds
View Abstract(Link to NCBI PubMed)
Pharmaceutics Research
Baba T., Nishino T., Tani T. J Trad Med 22, 284-289 (2005).
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Anti-diarrheal effects of wood creosote pill preparation compounded with four crude drugs on castor oil-induced diarrhea in rats and the role of crude drugs in the expression of the efficacy
Baba T., NishinoT., Tani T. J Trad Med 21, 137-142 (2004).
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Citri Unshiu Pericarpium prolongs mean residence time of guaiacol after oral administration of wood creosote pill to rats
Baba T., Nishino T., Tani T. Biol Pharm Bull 26, 194-198 (2003).
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Effects of herbal drugs prescribed in wood creosote pills on the dissolution profile of guaiacol
Chemical Analysis
Ogata N., Shibata T. Res Commun Mol Pathol Pharmacol 107, 167-173 (2000).
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Binding of alkyl- and alkoxy-substituted simple phenolic compounds to human serum proteins
View Abstract(Link to NCBI PubMed)
Ogata N., Baba T. Res Commun Chem Pathol Pharmacol 66, 411-423 (1989).
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Analysis of beechwood creosote by gas chromatography-mass spectrometry and high-performance liquid chromatography
View Abstract(Link to NCBI PubMed)
Norio Ogata and Takashi Shibata. J Gen Virol 89, 60-67 (2008).
First published online in 2007
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Protective effect of low-concentration chlorine dioxide gas against influenza A virus infection
Ogata N. Biochemistry 46, 4898-4911 (2007).
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Denaturation of protein by chlorine dioxide: oxidative modification of tryptophan and tyrosine residues
Morino H., Matsubara A., Fukuda T., Shibata T. Yakugaku Zasshi 127, 773-777 (2007).
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Inhibition of hyphal growth of the fungus Alternaria alternataby chlorine dioxide gas at very low concentrations
Biochemistry Research
Ogata N. Biochimie 89, 702-712 (2007).
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Elongation of palindromic repetitive DNA by DNA polymerase from hyperthermophilic archaea: A mechanism of DNA elongation and diversification
View Abstract(Link to NCBI PubMed)
Miura T. Viva Origino 31, 46-61 (2003).
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Origin of genomic DNA: discussion from reverse-transcription and expansion of repetitive oligonucleotides
Ogata N., Miura T. Biochemistry 39, 13993-14001 (2000).
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Elongation of tandem repetitive DNA by the DNA polymerase of the hyperthermophilic archaeon Thermococcus litoralis at a hairpin-coil transitional state: a model of amplification of a primordial simple DNA sequence
Ogata N., Miura T. Nucleic Acids Res 26, 4657-4661 (1998).
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Creation of genetic information by DNA polymerase of the thermophilic bacterium Thermus thermophilus
View Abstract(Link to NCBI PubMed)
Ogata N., Miura T. Nucleic Acids Res 26, 4652-4656 (1998).
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Creation of genetic information by DNA polymerase of the archaeon Thermococcus litoralis: influences of temperature and ionic strength
View Abstract(Link to NCBI PubMed)
Ogata N., Miura T. Biochem J 324, 667-671 (1997).
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Genetic information 'created' by archaebacterial DNA polymerase