Studies on the toxicity of beechwood creosote (3) Chronic toxicity and carcinogenicity in rats

Miyazato T., Suzuki A., Uenishi C., Yamanaka K. Oyo Yakuri 28, 925-947 (1984).

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山毛榉木馏油对于实验鼠的慢性毒性与致癌性实验

Studies on the toxicity of beechwood creosote (2) Chronic toxicity and carcinogenicity in mice

Miyazato T., Suzuki A., Nohno M., Yamanaka K. Oyo Yakuri 28, 909-924 (1984).

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山毛榉医用木馏油对大鼠的慢性毒性及致癌性试验

Wood creosote, the principal active ingredient of Seirogan, an herbal antidiarrheal medicine: a single-dose, dose-escalation safety and pharmacokinetic study

Kuge T., Shibata T., Willett M. S. Pharmacotherapy 23, 1391-1400 (2003).

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对健康受试者以多种用量单次给药正露丸主要成分医用木馏油的安全性及药效动力学试验

论文摘要

Multiple-dose escalation, safety, and tolerability study of wood creosote, the principal active ingredient of Seirogan, an herbal antidiarrheal medication, in healthy subjects

Kuge T., Shibata T., Willett M. S. J Clin Pharmacol 43, 284-290 (2003).

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对健康受试者以多种用量多次给药正露丸主要成分医用木馏油的安全性及耐受性试验

论文摘要

Stress-induced breakdown of intestinal barrier function in the rat: reversal by wood creosote

Kuge T., Greenwood-Van Meerveld B., Sokabe M. Life Sci 79, 913-918 (2006).

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医用木馏油能够使压力引起的胃肠道粘膜屏障的损伤得到恢复

论文摘要（链接至 NCBI PubMed）

Inhibition of rat intestinal Cl- secretion by 4,5-dimethylresorcinol

Ogata N., Shibata T. Pharmacology 72, 247-253 (2004).

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4,5-二甲基间苯二酚对大鼠肠道中氯离子分泌的抑制

论文摘要

Wood creosote inhibits calcium mobilization in guinea pig colonic smooth muscle

Morino H., Ataka K., Ito M., Kuge T. Biol Pharm Bull 27, 1046-1051 (2004).

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医用木馏油可抑制豚鼠结肠平滑肌内钙离子的动员

论文摘要

Seirogan (wood creosote) inhibits stress-induced ion secretion in rat intestinal epithelium

Ataka K., Kuge T., Venkova K., Greenwood-Van Meerveld B. Dig Dis Sci 48, 1303-1309 (2003).

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正露丸(医用木馏油)可抑制大鼠胃肠道上皮中由压力引起的氯离子分泌

论文摘要

Effects of Seirogan (wood creosote) on propulsive colonic motility and stool characteristics in ambulatory mini-pigs

Kuge T., Venkova K., Greenwood-Van Meerveld B. Dig Dis Sci 47, 2651-2656 (2002).

<标题>
正露丸(医用木馏油)对未拘束的迷你猪大肠蠕动及粪便特性(硬度)的影响

论文摘要

In vitro effects of wood creosote on enterotoxin-induced secretion measured
electrophysiologically in the rat jejunum and colon

Kuge T., Venkova K., Greenwood-Van Meerveld B. Biol Pharm Bull 24, 623-627 (2001).

<标题>
用电生理学测定医用木馏油对大鼠空场及结肠 In vitro 的肠毒素诱发性分泌的影响

论文摘要

Antidiarrheal activity of wood creosote: inhibition of muscle contraction and enterotoxin-induced fluid secretion in rabbit small intestine

Ogata N., Shibata T. Pharmacology 62, 181-187 (2001).

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医用木馏油的止泻作用:对兔子小肠肌肉收缩及肠毒素引起的肠液分泌的抑制

论文摘要

Comparison of the antidiarrheal effects of wood creosote and loperamide in the rat jejunum and colon in vitro

Greenwood-Van Meerveld B., Tyler K. R., Venkova K., Kuge T. Biol Pharm Bull 23, 952-956 (2000).

<标题>
In vitro医用木馏油及洛哌丁胺对大鼠空肠及结肠的止泻效果比较

论文摘要

Effect of wood creosote and loperamide on propulsive motility of mouse colon and small intestine

Ogata N., Ataka K., Morino H., Shibata T. Pharmacology 59, 212-220 (1999).

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医用木馏油及洛哌丁胺对于促进小鼠结肠及小肠蠕动的影响

论文摘要

Anti-diarrhoeal effects of Seirogan in the rat small intestine and colon examined in vitro

Greenwood-Van Meerveld B., Tyler K., Kuge T., Ogata N. Aliment Pharmacol Ther 13, 97-102 (1999).

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In vitro的正露丸对大鼠空肠及结肠的止泻效果

论文摘要（链接至 NCBI PubMed）

Inhibitory effect of creosote and its main components on production of verotoxin of enterohaemorrhagic Escherichia coli O157:H7

Sakagami Y., Ichise R., Kajimura K., Yokoyama H. Lett Appl Microbiol 28, 118-120 (1999).

<标题>
医用木馏油及其主要成分对于肠出血性大肠杆菌 O157:H7 的志贺样毒素生成的抑制作用

论文摘要（链接至 NCBI PubMed）

Effects of wood creosote on vero toxin-induced damage to rabbit jejunum

Shibata T., Ogata N. J New Remedies & Clinics 47, 765-771 (1998).

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医用木馏油对志贺样毒素损伤肠道粘膜的效果

论文摘要

Suppression of enterotoxin-induced intestinal fluid secretion by wood creosote

Ataka K., Ogata N., Kuge T., Shibata T. Res Commun Mol Pathol Pharmacol 93, 219-224 (1996).

<标题>
医用木馏油对肠毒素引起的肠液分泌的抑制

论文摘要（链接至 NCBI PubMed）

Suppression of intestinal smooth muscle contraction by 4-ethylguaiacol, a constituent of wood creosote

Toyoda M., Ogata N., Shibata T. Pharmacology 47, 300-308 (1993).

<标题>
医用木馏油的成分 4-乙基愈创木酚对于肠道平滑肌收缩的抑制

论文摘要

Demonstration of antidiarrheal and antimotility effects of wood creosote

Ogata N., Baba T., Shibata T. Pharmacology 46, 173-180 (1993).

<标题>
医用木馏油的止泻效果及蠕动抑制效果的实例

论文摘要

Citri Unshiu Pericarpium prolongs mean residence time of guaiacol after oral administration of wood creosote pill to rats

Baba T., NishinoT., Tani T. J Trad Med 21, 137-142 (2004).

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对大鼠经口给药医用木馏油丸后,陈皮粉可延长愈创木酚的平均滞留时间

Denaturation of protein by chlorine dioxide: oxidative modification of tryptophan and tyrosine residues

Ogata N. Biochemistry 46, 4898-4911 (2007).

<标题>
二氧化氯对蛋白质变性:色氨酸和酪氨酸残基的氧化修饰

论文摘要

论文摘要（日文翻译）

Origin of genomic DNA: discussion from reverse-transcription and expansion of repetitive oligonucleotides

Miura T. Viva Origino 31, 46-61 (2003).

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对基因组 DNA 的起源:由短链重复核酸的逆转录及扩张的考察

论文摘要

Elongation of tandem repetitive DNA by the DNA polymerase of the hyperthermophilic archaeon Thermococcus litoralis at a hairpin-coil transitional state: a model of amplification of a primordial simple DNA sequence

Ogata N., Miura T. Biochemistry 39, 13993-14001 (2000).

<标题>
超嗜热古菌 Thermococcus litoralis中 DNA 聚合酶在发夹-线圈迁移状态下造成的重复 DNA 的延长: 原始单纯的 DNA 排列的增幅模型

论文摘要

Creation of genetic information by DNA polymerase of the thermophilic bacterium Thermus thermophilus

Ogata N., Miura T. Nucleic Acids Res 26, 4657-4661 (1998).

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由嗜热菌 Thermus thermophilus 中 DNA 聚合酶创造基因信息

论文摘要（链接至 NCBI PubMed）

Creation of genetic information by DNA polymerase of the archaeon Thermococcus litoralis: influences of temperature and ionic strength

Ogata N., Miura T. Nucleic Acids Res 26, 4652-4656 (1998).

<标题>
由古菌 Thermococcus litoralis 中 DNA 聚合酶创造基因信息:温度及离子强度的影响

论文摘要（链接至 NCBI PubMed）