<Title>
Lack of oncogenicity of wood creosote, the principal active ingredient of Seirogan, an herbal antidiarrheal medication, in Sprague-Dawley rats

View Abstract(Link to NCBI PubMed)

Studies on the toxicity of beechwood creosote (3) Chronic toxicity and carcinogenicity in rats

Miyazato T., Suzuki A., Uenishi C., Yamanaka K. Oyo Yakuri 28, 925-947 (1984).

<Title>
Studies on the toxicity of beechwood creosote Chronic toxicity and carcinogenicity in rats

Studies on the toxicity of beechwood creosote (2) Chronic toxicity and carcinogenicity in rats

Miyazato T., Suzuki A., Uenishi C., Yamanaka K. Oyo Yakuri 28, 909-924 (1984).

<Title>
Studies on the toxicity of beechwood creosote Chronic toxicity and carcinogenicity in rats

Studies on the toxicity of beechwood creosote (1) Chronic toxicity and carcinogenicity in rats

Miyazato T., Suzuki A., Uenishi C., Yamanaka K. Oyo Yakuri 21, 899-919 (1981).

<Title>
Studies on the toxicity of beechwood creosote 1. Acute and subacute toxicity

Clinical Research

Multicenter, double-blind, randomized comparison of wood creosote, the principal active ingredient of Seirogan, an herbal antidiarrheal medication, and loperamide in adults with acute nonspecific diarrhea

Kuge T., Shibata T., Willett M. S. Clin Ther 26, 1644-51 (2004).

<Title>
Multicenter, double-blind, randomized comparison of wood creosote, the principal active ingredient of Seirogan, an herbal antidiarrheal medication, and loperamide in adults with acute nonspecific diarrhea

View Abstract(Link to NCBI PubMed)

Wood creosote, the principal active ingredient of Seirogan, an herbal antidiarrheal medicine: a single-dose, dose-escalation safety and pharmacokinetic study

Kuge T., Shibata T., Willett M. S. Pharmacotherapy 23, 1391-1400 (2003).

<Title>
Wood creosote, the principal active ingredient of Seirogan, an herbal antidiarrheal medicine: a single-dose, dose-escalation safety and pharmacokinetic study

View Abstract

Multiple-dose escalation, safety, and tolerability study of wood creosote, the principal active ingredient of Seirogan, an herbal antidiarrheal medication, in healthy subjects

Kuge T., Shibata T., Willett M. S. J Clin Pharmacol 43, 284-290 (2003).

<Title>
Multiple-dose escalation, safety, and tolerability study of wood creosote, the principal active ingredient of Seirogan, an herbal antidiarrheal medication, in healthy subjects

View Abstract

Pharmacokinetics of wood creosote: glucuronic acid and sulfate conjugation of phenolic compounds

Ogata N., Matsushima N., Shibata T. Pharmacology 51, 195-204 (1995).

<Title>
Pharmacokinetics of wood creosote: glucuronic acid and sulfate conjugation of phenolic compounds

View Abstract

Pharmacology Research

Wood creosote prevents CRF-induced motility via 5-HT3 receptors in proximal and 5-HT4 receptors in distal colon in rats

Ataka K., Kuge T., Fujino K., Takahashi T., Fujimiya M. Auton Neurosci 133, 136-145 (2007).

<Title>
Wood creosote prevents CRF-induced motility via 5-HT3 receptors in proximal and 5-HT4 receptors in distal colon in rats

View Abstract(Link to NCBI PubMed)

Stress-induced breakdown of intestinal barrier function in the rat: reversal by wood creosote

Kuge T., Greenwood-Van Meerveld B., Sokabe M. Life Sci 79, 913-918 (2006).

<Title>
Stress-induced breakdown of intestinal barrier function in the rat: reversal by wood creosote

View Abstract(Link to NCBI PubMed)

Inhibition of rat intestinal Cl- secretion by 4,5-dimethylresorcinol

Ogata N., Shibata T. Pharmacology 72, 247-253 (2004).

<Title>
Inhibition of rat intestinal Cl- secretion by 4,5-dimethylresorcinol

View Abstract

Wood creosote inhibits calcium mobilization in guinea pig colonic smooth muscle

Morino H., Ataka K., Ito M., Kuge T. Biol Pharm Bull 27, 1046-1051 (2004).

<Title>
Wood creosote inhibits calcium mobilization in guinea pig colonic smooth muscle

View Abstract

Seirogan (wood creosote) inhibits stress-induced ion secretion in rat intestinal epithelium

Ataka K., Kuge T., Venkova K., Greenwood-Van Meerveld B. Dig Dis Sci 48, 1303-1309 (2003).

<Title>
Seirogan (wood creosote) inhibits stress-induced ion secretion in rat intestinal epithelium

View Abstract

Effects of Seirogan (wood creosote) on propulsive colonic motility and stool characteristics in ambulatory mini-pigs

Kuge T., Venkova K., Greenwood-Van Meerveld B. Dig Dis Sci 47, 2651-2656 (2002).

<Title>
Effects of Seirogan (wood creosote) on propulsive colonic motility and stool characteristics in ambulatory mini-pigs

View Abstract

In vitro effects of wood creosote on enterotoxin-induced secretion measured
electrophysiologically in the rat jejunum and colon

Kuge T., Venkova K., Greenwood-Van Meerveld B. Biol Pharm Bull 24, 623-627 (2001).

<Title>
In vitro effects of wood creosote on enterotoxin-induced secretion measured electrophysiologically in the rat jejunum and colon

View Abstract

Antidiarrheal activity of wood creosote: inhibition of muscle contraction and enterotoxin-induced fluid secretion in rabbit small intestine

Ogata N., Shibata T. Pharmacology 62, 181-187 (2001).

<Title>
Antidiarrheal activity of wood creosote: inhibition of muscle contraction and enterotoxin-induced fluid secretion in rabbit small intestine

View Abstract

Comparison of the antidiarrheal effects of wood creosote and loperamide in the rat jejunum and colon in vitro

Greenwood-Van Meerveld B., Tyler K. R., Venkova K., Kuge T. Biol Pharm Bull 23, 952-956 (2000).

<Title>
Comparison of the antidiarrheal effects of wood creosote and loperamide in the rat jejunum and colon In vitro

View Abstract

Effect of wood creosote and loperamide on propulsive motility of mouse colon and small intestine

Ogata N., Ataka K., Morino H., Shibata T. Pharmacology 59, 212-220 (1999).

<Title>
Effect of wood creosote and loperamide on propulsive motility of mouse colon and small intestine

View Abstract

Anti-diarrhoeal effects of Seirogan in the rat small intestine and colon examined in vitro

Greenwood-Van Meerveld B., Tyler K., Kuge T., Ogata N. Aliment Pharmacol Ther 13, 97-102 (1999).

<Title>
Anti-diarrhoeal effects of Seirogan in the rat small intestine and colon examined In vitro

View Abstract(Link to NCBI PubMed)

Inhibitory effect of creosote and its main components on production of verotoxin of enterohaemorrhagic Escherichia coli O157:H7

Sakagami Y., Ichise R., Kajimura K., Yokoyama H. Lett Appl Microbiol 28, 118-120 (1999).

<Title>
Inhibitory effect of creosote and its main components on production of verotoxin of enterohaemorrhagic Escherichia coli O157:H7

View Abstract(Link to NCBI PubMed)

Effects of wood creosote on vero toxin-induced damage to rabbit jejunum

Shibata T., Ogata N. J New Remedies & Clinics 47, 765-771 (1998).

<Title>
Effects of wood creosote on vero toxin-induced damage to rabbit jejunum

View Abstract

Suppression of enterotoxin-induced intestinal fluid secretion by wood creosote

Ataka K., Ogata N., Kuge T., Shibata T. Res Commun Mol Pathol Pharmacol 93, 219-224 (1996).

<Title>
Suppression of enterotoxin-induced intestinal fluid secretion by wood creosote

View Abstract(Link to NCBI PubMed)

Suppression of intestinal smooth muscle contraction by 4-ethylguaiacol, a constituent of wood creosote

Toyoda M., Ogata N., Shibata T. Pharmacology 47, 300-308 (1993).

<Title>
Suppression of intestinal smooth muscle contraction by 4-ethylguaiacol, a constituent of wood creosote

View Abstract

Demonstration of antidiarrheal and antimotility effects of wood creosote

Ogata N., Baba T., Shibata T. Pharmacology 46, 173-180 (1993).

<Title>
Demonstration of antidiarrheal and antimotility effects of wood creosote

View Abstract

Suppression of intestinal smooth muscle contraction by phenolic compounds

Ogata N., Toyoda M., Shibata T. Res Commun Chem Pathol Pharmacol 77, 359-366 (1992).

<Title>
Suppression of intestinal smooth muscle contraction by phenolic compounds

View Abstract(Link to NCBI PubMed)

Pharmaceutics Research

Anti-diarrheal effects of wood creosote pill preparation compounded with four crude drugs on castor oil-induced diarrhea in rats and the role of crude drugs in the expression of the efficacy

Baba T., Nishino T., Tani T. J Trad Med 22, 284-289 (2005).

<Title>
Anti-diarrheal effects of wood creosote pill preparation compounded with four crude drugs on castor oil-induced diarrhea in rats and the role of crude drugs in the expression of the efficacy

Citri Unshiu Pericarpium prolongs mean residence time of guaiacol after oral administration of wood creosote pill to rats

Baba T., NishinoT., Tani T. J Trad Med 21, 137-142 (2004).

<Title>
Citri Unshiu Pericarpium prolongs mean residence time of guaiacol after oral administration of wood creosote pill to rats

Effects of herbal drugs prescribed in wood creosote pills on the dissolution profile of guaiacol

Baba T., Nishino T., Tani T. Biol Pharm Bull 26, 194-198 (2003).

<Title>
Effects of herbal drugs prescribed in wood creosote pills on the dissolution profile of guaiacol

View Abstract

Chemical Analysis

Binding of alkyl- and alkoxy-substituted simple phenolic compounds to human serum proteins

Ogata N., Shibata T. Res Commun Mol Pathol Pharmacol 107, 167-173 (2000).

<Title>
Binding of alkyl- and alkoxy-substituted simple phenolic compounds to human serum proteins

View Abstract(Link to NCBI PubMed)

Analysis of beechwood creosote by gas chromatography-mass spectrometry and high-performance liquid chromatography

Ogata N., Baba T. Res Commun Chem Pathol Pharmacol 66, 411-423 (1989).

<Title>
Analysis of beechwood creosote by gas chromatography-mass spectrometry and high-performance liquid chromatography

View Abstract(Link to NCBI PubMed)

ClO2 Research

Protective effect of low-concentration chlorine dioxide gas against influenza A virus infection

Norio Ogata and Takashi Shibata. J Gen Virol 89, 60-67 (2008).
First published online in 2007

<Title>
Protective effect of low-concentration chlorine dioxide gas against influenza A virus infection

View Abstract

Denaturation of protein by chlorine dioxide: oxidative modification of tryptophan and tyrosine residues

Ogata N. Biochemistry 46, 4898-4911 (2007).

<Title>
Denaturation of protein by chlorine dioxide: oxidative modification of tryptophan and tyrosine residues

View Abstract

Inhibition of hyphal growth of the fungus Alternaria alternata by chlorine dioxide gas at very low concentrations

Morino H., Matsubara A., Fukuda T., Shibata T. Yakugaku Zasshi 127, 773-777 (2007).

<Title>
Inhibition of hyphal growth of the fungus Alternaria alternataby chlorine dioxide gas at very low concentrations

View Abstract

Other Research

Biochemistry Research

Elongation of palindromic repetitive DNA by DNA polymerase from hyperthermophilic archaea: A mechanism of DNA elongation and diversification

Ogata N. Biochimie 89, 702-712 (2007).

<Title>
Elongation of palindromic repetitive DNA by DNA polymerase from hyperthermophilic archaea: A mechanism of DNA elongation and diversification

View Abstract(Link to NCBI PubMed)

Origin of genomic DNA: discussion from reverse-transcription and expansion of repetitive oligonucleotides

Miura T. Viva Origino 31, 46-61 (2003).

<Title>
Origin of genomic DNA: discussion from reverse-transcription and expansion of repetitive oligonucleotides

View Abstract

Elongation of tandem repetitive DNA by the DNA polymerase of the hyperthermophilic archaeon Thermococcus litoralis at a hairpin-coil transitional state: a model of amplification of a primordial simple DNA sequence

Ogata N., Miura T. Biochemistry 39, 13993-14001 (2000).

<Title>
Elongation of tandem repetitive DNA by the DNA polymerase of the hyperthermophilic archaeon Thermococcus litoralis at a hairpin-coil transitional state: a model of amplification of a primordial simple DNA sequence

View Abstract