刊载大幸药品关于木榴油和二氧化氯的研究成果

木馏油的研究

综述

安全性相关研究

临床研究

药理学研究

制药学研究

化学分析

二氧化氯相关研究

其他研究

木馏油的研究

综述

New views on antidiarrheal effect of wood creosote: Is wood creosote really a gastrointestinal antiseptic?
Ataka K., Ito M., Shibata T. YAKUGAKU ZASSHI 125, 937-950 (2005).

＜标题＞

关于木榴油止泻作用的新观点

论文全文

Wood creosote: a historical study and its preparation in combination with herbal drugs
Baba T., Tani T. Yakushigaku Zasshi 36,10-17 (2001).

＜标题＞

木馏油及其复方制剂的来历

论文大纲

安全性相关研究

Lack of oncogenicity of wood creosote, the principal active ingredient of Seirogan, an herbal antidiarrheal medication, in Sprague-Dawley rats
Kuge T., Shibata T., Willett M. S., Turck P., Traul K. A. Int J Toxicol 20, 297-305 (2001).

＜标题＞

中药止泻药（正露丸）主要有效成分木馏油在Sprague-Dawley（远交群）大鼠体内未见致癌性

论文大纲（NCBI PubMed 链接）

Studies on the toxicity of beechwood creosote (3) Chronic toxicity and carcinogenicity in rats
Miyazato T., Suzuki A., Uenishi C., Yamanaka K. Oyo Yakuri 28, 925-947 (1984).

＜标题＞

山毛榉木馏油在大鼠体内的慢性毒性及致癌性试验

Studies on the toxicity of beechwood creosote (2) Chronic toxicity and carcinogenicity in rats
Miyazato T., Suzuki A., Uenishi C., Yamanaka K. Oyo Yakuri 28, 909-924 (1984).

＜标题＞

山毛榉木馏油在小鼠体内的慢性毒性及致癌性试验

Studies on the toxicity of beechwood creosote (1) Chronic toxicity and carcinogenicity in rats
Miyazato T., Suzuki A., Uenishi C., Yamanaka K. Oyo Yakuri 21, 899-919 (1981).

＜标题＞

山毛榉木馏油在小鼠及大鼠体内的急性及亚急性毒性试验

临床研究

Multicenter, double-blind, randomized comparison of wood creosote, the principal active ingredient of Seirogan, an herbal antidiarrheal medication, and loperamide in adults with acute nonspecific diarrhea
Kuge T., Shibata T., Willett M. S. Clin Ther 26, 1644-51 (2004).

＜标题＞

中药止泻药正露丸主要成分木馏油及洛派丁胺对成人急性非特异性痢疾的多中心无作为双盲试验

论文大纲（NCBI PubMed 链接）

Wood creosote, the principal active ingredient of Seirogan, an herbal antidiarrheal medicine: a single-dose, dose-escalation safety and pharmacokinetic study
Kuge T., Shibata T., Willett M. S. Pharmacotherapy 23, 1391-1400 (2003).

＜标题＞

正露丸主要成分木馏油对健康试验对象单次多用量给药的安全性、药力学试验

论文大纲

Multiple-dose escalation, safety, and tolerability study of wood creosote, the principal active ingredient of Seirogan, an herbal antidiarrheal medication, in healthy subjects
Kuge T., Shibata T., Willett M. S. J Clin Pharmacol 43, 284-290 (2003).

＜标题＞

正露丸主要成分木馏油对健康试验对象多次多用量给药的安全性、耐性试验

论文大纲

Pharmacokinetics of wood creosote: glucuronic acid and sulfate conjugation of phenolic compounds
Ogata N., Matsushima N., Shibata T. Pharmacology 51, 195-204 (1995).

＜标题＞

木馏油的药物动态：酚类化合物的葡萄糖醛化合及硫酸化合

论文大纲

药理学研究

Wood creosote prevents CRF-induced motility via 5-HT3 receptors in proximal and 5-HT4 receptors in distal colon in rats
Ataka K., Kuge T., Fujino K., Takahashi T., Fujimiya M. Auton Neurosci 133, 136-145 (2007).

＜标题＞

木馏油在近位和远位结肠中介入被诱体，抑制CRF所致的大鼠结肠运动亢进

论文大纲（NCBI PubMed 链接）

Stress-induced breakdown of intestinal barrier function in the rat: reversal by wood creosote
Kuge T., Greenwood-Van Meerveld B., Sokabe M. Life Sci 79, 913-918 (2006).

＜标题＞

精神压力诱发的消化器官屏障崩溃：通过木馏油进行恢复

论文大纲（NCBI PubMed 链接）

Inhibition of rat intestinal Cl- secretion by 4,5-dimethylresorcinol
Ogata N., Shibata T. Pharmacology 72, 247-253 (2004).

＜标题＞

4,5-二甲基间苯二酚对大鼠肠道氯离子分泌的阻碍作用

论文大纲

Wood creosote inhibits calcium mobilization in guinea pig colonic smooth muscle
Morino H., Ataka K., Ito M., Kuge T. Biol Pharm Bull 27, 1046-1051 (2004).

＜标题＞

通过木馏油阻碍豚鼠结肠平滑肌内的钙动员

论文大纲

Seirogan (wood creosote) inhibits stress-induced ion secretion in rat intestinal epithelium
Ataka K., Kuge T., Venkova K., Greenwood-Van Meerveld B. Dig Dis Sci 48, 1303-1309 (2003).

＜标题＞

通过正露丸（木馏油）抑制精神压力诱发的大鼠消化器官上皮中的离子分泌

论文大纲

Seirogan (wood creosote) inhibits stress-induced ion secretion in rat intestinal epithelium
Ataka K., Kuge T., Venkova K., Greenwood-Van Meerveld B. Dig Dis Sci 47, 2651-2656 (2002).

＜标题＞

正露丸（木馏油）对非拘束迷你猪大肠蠕动和大便特性（硬度）的影响

论文大纲

In vitro effects of wood creosote on enterotoxin-induced secretion measured
electrophysiologically in the rat jejunum and colon
Kuge T., Venkova K., Greenwood-Van Meerveld B. Biol Pharm Bull 24, 623-627 (2001).

＜标题＞

木馏油对根据电生理学测定的大鼠空肠及结肠中In vitro（离体的）内毒素诱发性分泌的影响

论文大纲

Pharmacokinetics of wood creosote: inhibition of muscle contraction and enterotoxin-induced fluid secretion in rabbit small intestine
Ogata N., Shibata T. Pharmacology 62, 181-187 (2001).

＜标题＞

木馏油的止泻活性：兔子小肠肌肉收缩及内毒素诱发性肠液分泌的抑制

论文大纲

Comparison of the antidiarrheal effects of wood creosote and loperamide in the rat jejunum and colon in vitro
Greenwood-Van Meerveld B., Tyler K. R., Venkova K., Kuge T. Biol Pharm Bull 23, 952-956 (2000).

＜标题＞

In vitro（离体）大鼠空肠及结肠中木馏油及洛派丁胺止泻效果的比较

论文大纲

Effect of wood creosote and loperamide on propulsive motility of mouse colon and small intestine
Ogata N., Ataka K., Morino H., Shibata T. Pharmacology 59, 212-220 (1999).

＜标题＞

木馏油及洛派丁胺对小鼠结肠及小肠推进运动性的影响

论文大纲

Anti-diarrhoeal effects of Seirogan in the rat small intestine and colon examined in vitro
Greenwood-Van Meerveld B., Tyler K., Kuge T., Ogata N. Aliment Pharmacol Ther 13, 97-102 (1999).

＜标题＞

正露丸在In vitro（离体）大鼠空肠及结肠中的止泻效果

论文大纲（NCBI PubMed 链接）

Inhibitory effect of creosote and its main components on production of verotoxin of enterohaemorrhagic Escherichia coli O157:H7
Sakagami Y., Ichise R., Kajimura K., Yokoyama H. Lett Appl Microbiol 28, 118-120 (1999).

＜标题＞

肠出血性大肠杆菌0157：木馏油及其主要成分对H7的志贺样毒素产生的抑制效果

论文大纲（NCBI PubMed 链接）

Effects of wood creosote on vero toxin-induced damage to rabbit jejunum
Shibata T., Ogata N. J New Remedies & Clinics 47, 765-771 (1998).

＜标题＞

木馏油对志贺样毒素所致肠道粘膜损伤的效果

论文大纲

Suppression of enterotoxin-induced intestinal fluid secretion by wood creosote
Ataka K., Ogata N., Kuge T., Shibata T. Res Commun Mol Pathol Pharmacol 93, 219-224 (1996).

＜标题＞

木馏油对内毒素诱发性肠液分泌的抑制

论文大纲（NCBI PubMed 链接）

Suppression of intestinal smooth muscle contraction by 4-ethylguaiacol, a constituent of wood creosote
Toyoda M., Ogata N., Shibata T. Pharmacology 47, 300-308 (1993).

＜标题＞

木馏油成分4乙基愈创木酚对肠道平滑肌收缩的抑制

论文大纲

Demonstration of antidiarrheal and antimotility effects of wood creosote
Ogata N., Baba T., Shibata T. Pharmacology 46, 173-180 (1993).

＜标题＞

木馏油的止泻效果及运动抑制效果的验证

论文大纲

Suppression of intestinal smooth muscle contraction by phenolic compounds
Ogata N., Toyoda M., Shibata T. Res Commun Chem Pathol Pharmacol 77, 359-366 (1992).

＜标题＞

酚类化合物对肠道平滑肌收缩的抑制

论文大纲（NCBI PubMed 链接）

制药学研究

Anti-diarrheal effects of wood creosote pill preparation compounded with four crude drugs on castor oil-induced diarrhea in rats and the role of crude drugs in the expression of the efficacy
Baba T., Nishino T., Tani T. J Trad Med 22, 284-289 (2005).

＜标题＞

蓖麻油所致大鼠痢疾中含有4种药材的木馏油丸的止泻效果，以及药材在功效中所起的作用

Citri Unshiu Pericarpium prolongs mean residence time of guaiacol after oral administration of wood creosote pill to rats
Baba T., NishinoT., Tani T. J Trad Med 21, 137-142 (2004).

＜标题＞

陈皮在木馏油丸向大鼠经口给药后延长愈创木酚的平均滞留时间

Effects of herbal drugs prescribed in wood creosote pills on the dissolution profile of guaiacol
Baba T., Nishino T., Tani T. Biol Pharm Bull 26, 194-198 (2003).

＜标题＞

木馏油丸中所用药材对愈创木酚析出动态的效果

论文大纲

化学分析

Binding of alkyl- and alkoxy-substituted simple phenolic compounds to human serum proteins
Ogata N., Shibata T. Res Commun Mol Pathol Pharmacol 107, 167-173 (2000).

＜标题＞

通过烷基及烷氧基置换的单纯酚类化合物与人血清蛋白质的结合

论文大纲（NCBI PubMed 链接）

Analysis of beechwood creosote by gas chromatography-mass spectrometry and high-performance liquid chromatography
Ogata N., Baba T. Res Commun Chem Pathol Pharmacol 66, 411-423 (1989).

＜标题＞

山毛榉木馏油通过气相色谱、质量分析法以及高速液体色谱法进行的分析

论文大纲（NCBI PubMed 链接）

二氧化氯相关研究

Protective effect of low-concentration chlorine dioxide gas against influenza A virus infection
Norio Ogata and Takashi Shibata. J Gen Virol 89, 60-67 (2008).
First published online in 2007

＜标题＞

低浓度二氧化氯气体对A型流感病毒的预防效果

论文大纲
论文大纲（日文版）

Denaturation of protein by chlorine dioxide: oxidative modification of tryptophan and tyrosine residues
Ogata N. Biochemistry 46, 4898-4911 (2007).

＜标题＞

二氧化氯引起的蛋白质变性：色氨酸与酪氨酸残基的氧化性修饰

论文大纲
论文大纲（日文版）

Inhibition of hyphal growth of the fungus Alternaria alternata by chlorine dioxide gas at very low concentrations
Morino H., Matsubara A., Fukuda T., Shibata T. Yakugaku Zasshi 127, 773-777 (2007).

＜标题＞

极低浓度二氧化氯气体对Alternaria alternata真菌菌丝成长的抑制

论文大纲

其他研究

生化学研究

Elongation of palindromic repetitive DNA by DNA polymerase from hyperthermophilic archaea: oxidative modification of tryptophan and tyrosine residues
Ogata N. Biochemistry 89, 702-712 (2007).

＜标题＞

嗜热菌的DNA聚合酶诱导的返回序列DNA延伸：DNA延伸及多样化的机制

论文大纲（NCBI PubMed 链接）

Origin of genomic DNA: discussion from reverse-transcription and expansion of repetitive oligonucleotides
Miura T. Viva Origino 31, 46-61 (2003).

＜标题＞

基因组DNA的起源：重复性寡核苷酸的逆转录及伸长合成的考察

论文大纲

Elongation of tandem repetitive DNA by the DNA polymerase of the hyperthermophilic archaeon Thermococcus litoralis at a hairpin-coil transitional state: a model of amplification of a primordial simple DNA sequence
Ogata N., Miura T. Biochemistry 39, 13993-14001 (2000).

＜标题＞

极端嗜热菌Thermococcus litoralis的DNA聚合酶引起的发夹－线团转化状态中的重复DNA的伸长：原始单纯DNA排列的增幅模型

论文大纲

Creation of genetic information by DNA polymerase of the thermophilic bacterium Thermus thermophilus
Ogata N., Miura T. Nucleic Acids Res 26, 4657-4661 (1998).

＜标题＞

嗜热菌Thermus thermophilus的DNA聚合酶的遗传信息创造作用

论文大纲（NCBI PubMed 链接）

Creation of genetic information by DNA polymerase of the archaeon Thermococcus litoralis: influences of temperature and ionic strength
Ogata N., Miura T. Nucleic Acids Res 26, 4652-4656 (1998).

＜标题＞

古细菌 Thermococcus litoralis 的DNA聚合酶的遗传信息创造作用：温度与离子强度的影响

论文大纲（NCBI PubMed 链接）

Genetic information 'created' by archaebacterial DNA polymerase
Ogata N., Miura T. Biochem J 324, 667-671 (1997).

＜标题＞

由古细菌的DNA聚合酶创造的遗传信息

论文大纲